Pumpkin seeds nih. 2006 Jun;61(2):73-80.

Pumpkin seeds nih Preparation of Pumpkin Seed Extract. Here, we evaluated the antioxidant properties of pumpkin (Cucurbita pepo L. ) as a promising drug to healing wounds in animal assays. 2S albumins and 11S globulins, two storage proteins involved in pumpkin seeds allergy Clipboard, Search History, and several other advanced features are temporarily unavailable. , seed-cakes). However, there is insufficient information about the possible biochemical rationale behind this practice. Pumpkin seed powder (100 g) was dissolved in 1 L of distilled water (DW) and incubated overnight at 20 Pumpkin seeds’ decoction was performed by boiling 250 g from seeds without husk of pumpkin with distilled water at 100 °C three times each for one h (3 × 1L). The study was performed on 30 male rats divided into three groups: a control group (CD), CD-chol group fed diet Reactive oxygen species play a crucial role in the pathogenesis of diabetes and its complications. Raw Seed proteins extracted from Tunisian pumpkin seeds ( Cucurbita maxima ) were investigated for their solubility properties and sequentially extracted according to the Osborne procedure. Four groups, each comprising 12 mice, were established. 100 mg/kg of This study aimed to characterize the lipid fractions and the seeds of pumpkin (Cucurbita sp) varieties Nova Caravela, Mini Paulista, Menina Brasileira, and Moranga de Mesa aiming at using them in food. Pumpkin is a well-known multifunctional ingredient in the diet, full of nutrients, and has opened new vistas for scientists during the past years. 01 and p=0. 56% in pumpkin seed oil extracted by pentane, whereas the content of linoleic acid ranged from 43. Two experimental patterns were studied, an Colonoscopy image of pumpkin seed bezoar in the rectum. Macroscopically, alterations in helminthic motility are present at a dose of > 23 gr. Background Background: Pumpkin seed oil is valuable oil for its distinctive taste and aroma, as well as supposed health- promoting properties. The objective was to determine dominant volatiles in raw and roasted pumpkin seeds, and the effect of seed coat, moisture content, fatty acid ratio, total lipids, reducing sugars, and harvest year on volatile formation. In the present study, the effects of treatment with pumpkin seed oil on hypertension induced by the nitric oxide synthase inhibitor N(ω)-nitro-L-arginine methyl ester hydrochloride (L-NAME) (50 mg /kg/day) in rats were studied and compared with those of the calcium channel Objective: To assess the efficacy of drugs containing herbal extracts in the treatment of Benign Prostatic Hyperplasia. Pumpkin (Cucurbita pepo L. Due to its colour and the foam formation, the oil cannot be used for cooking Background: Nitrate (NO3) is the most common chemical contaminant in the world's ground water aquifer. The water-holding capacity of pumpkin seed albumin concentrate was higher than that of the albumin concentrates from roselle seed (0. The aim of this study was to investigate how roasting pumpkin seeds influences the physicochemical properties of cold-pressed oils. of pumpkin seed in 100 ml. g. Introduction. This study evaluates the potential effects of pumpkin seeds protein on blood pressure (BP), plasma adiponectin, leptin levels, and oxidative stress in rats with fructose-induced metabolic syndrome. 41 mL/g) . 007 and p=0. Here, the aim is to assess in vitro, the anticancer and antidiabetic properties of Results: Respondents indicated pumpkin seeds as the most commonly consumed seeds (45. styriaca (a medicinal variety of pumpkin, the “Styrian oil pumpkin”), which was investigated in the current study. ) is an annual climber plant, and its seeds have considerable amount of oil with nutritional and medicinal importance. At the same time, the fatty acids from pumpkin seeds also have shown antiobesity effects in human trials . The seed oil is used as salad oil in Europe, and in India for cooking and lighting. Skip to main page content NIH; HHS; USA. No significant difference was observed in AChE activities of Pumpkin flesh, peel and seeds powders have sufficient crude fiber and proteins, especially pumpkin seeds proteins with essential amino acids and peptides, which are responsible for In southwestern Nigeria, pumpkin seeds are used locally as an alternative to “egusi” melon (Citrullus vulgaris Schrad) seed. The rats were grouped into 7. Introduction: The German Research Activities on Natural Urologicals (GRANU) study was a randomized, partially blinded, placebo-controlled, parallel-group trial that investigated the efficacy of pumpkin seed in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS). pepo exhibit better antioxidant properties, regardless of the extraction solvent used. Methods: This single-blind randomized clinical trial included patients with BPH aged ≥ 50 years referred to the Urology Clinic of Shahid Beheshti Hospital, Hamadan, Iran, from Pumpkin seed kernel flour had higher values of chemical score, essential amino acid index, and in vitro protein digestibility than the other flours examined. 1 from Whatman. Therefore, the objective of present study is to study the influence of roasting (120, 160, and 200°C for 10 min) on the phenolics content, flavonoids content Oil absorption capacity of pumpkin seed protein isolate and hydrolysate: The oil absorption capacity increased in pumpkin seed protein hydrolysate compared to its isolate (Figure 2) which can be related to an increase in surface hydrophobicity after enzymatic hydrolysis that leads to an increase in physical entrapment of oil droplets. subsp. Pumpkin seed oil is used primarily as a food flavoring. Materials and methods: 40 male albino rats were divided into four groups: control group, hypercholesterolemic rats, fed the balanced diet supplemented with cholesterol at a dose level of 2 g/100 g diet; the other two groups of animals fed the same previous hypercholesterolemic diet supplemented with either flax/pumpkin seed mixture or pumpkin Hemani pumpkin seed oil was provided from a local market. of pumpkin seed meal; group 3 was treated with Albendazole 5 %, at the dosage of 1 mL/10 kg l. Twenty four male Wistar albino rats were divided into four groups and fed a 20% casein diet, 20% casei Pumpkin seed oil (PSO) is a hygienic addition in diet of human and has potential appropriateness for both nutritional and industrial uses (Stevenson et al. pepo L. Puppies were infected through feeding on the muscles of Mugil sp. The goal of the current work was to assess the nutritional profile and phytochemical properties of cucurbit (Cucurbita maxima L. Prior to protein isolation, the fraction with a particle size of 300–600 µm was suspended in hexane at a ratio of 1:3 (w/v) for 40 min at room temperature Anti-inflammatory properties of pumpkin seeds have been proposed as another mechanism for the effectiveness of pumpkin seed oil in BPH . 2. , 1996). No treatment; B. w. The animals were cared for according to the published NIH guideline. 1. 70 and 4. In a single-arm, mono-center pilot study, the effects of a proprietary oil Among many phytotherapeutic compounds available and studied in the literature, pumpkin seed extract, soy germ isoflavonoids, and cranberry have shown efficacy and safety in the treatment of LUTS. This study aims to examine the effects of flax and pumpkin powder seed mixture on alloxan induced diabetes in Wistar rats. Eight healthy female, single or non pregnant subjects, aged 20-37 y The tocopherol profile of the studied pumpkin samples (seeds and seed cake) is described in Table 2. 19% of women and 53. Background: Increasing natural drug demand for pharmaceutical uses has encouraged scientifics all over the world to explore medicinal plants recognized as efficient remedies. 004, respectively) and significantly lower protein levels within both lobes (p=0. The optical density was measured at λ = 727 Pumpkin seed is not your regular fruit seed. The peptide fractions with the highest zinc-ch Statement of Significance: This article proposes that future nut research should expand to include seeds, in order to support the development of specific recommendations for nuts and seeds as a food group, which is more aligned with the major dietary guidelines. This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of PSO for treatment of hair growth in male patients with mild to moderate androgenetic alopecia (AGA). Pumpkin is a well-known multifunctional ingredient in the diet, full of nutrients, and has opened new vistas for scientists during the past years. Biopsies were taken of this area which subsequently returned as negative. In this context, extracted oil from pumpkin seeds (Cucurbita pepo L. Pumpkin seed oil has been reported to be effective in improving BPH and other LUTS (10, 11). Aim: The present study aimed to investigate the clinical efficacy of pumpkin seed oil (PSO) in the treatment of female pattern hair loss (FPHL) and compare its effects with minoxidil 5% foam. Epub 2010 Nov 23. Pumpkin seeds (Cucurbita sp. 16–5. There is a protheolithic effect with an average survival time Pumpkin seed products (raw, roasted, autoclaved, germinated, fermented, pumpkin protein concentrate and pumpkin protein isolate) were incorporated into wheat flour to produce blends with protein levels of 15, 17, 19 and 21%. 1. Proteins from 11 plant-seeds were extracted and tested their cytoaffinity as gelatin replacer by grafting them on alginate microbeads and pumpkin seed protein coated microbeads shown the best performance in stimulating proliferation of C2C12 cells (by 17 folds in a week), 3T3-L1 adipocytes, chicken muscle satellite cells and primary porcine Squash pumpkin is greatly used in Portugal and as by-products of its processing are generated tons of shell and seeds. Administration of formaldehyde (FA) caused significant elevat Background: Postmenopausal women have a higher prevalence of hypertension than age-match men. Moreover, we assessed whether proteins from pumpkin seed lowered the Background: Pumpkin seed oil is widely used to treat benign prostatic hyperplasia (BPH), a common disease in elder men. 86% in pumpkin seed oil extracted by pentane to 46. ) seeds, seed oils and oil extraction by-products (e. Methods: The clinical trial study was performed in 2011-2012 at Imam Reza Hospital, Mashhad, Iran. The nutritional composition of pumpkin native to central Italy, locally known as “Berrettina” (Cucurbita maxima L. Our results provide evidence for a reduced postmenopausal breast cancer risk associated with increased consumption of sunflower and pumpkin seeds and Twelve pumpkin cultivars (Cucurbita maxima D. of distilled water can produce an antihelminthic effect. ) and/or PSO (1 mL/kg b. ) seed oil production was kindly provided by Estyria Naturprodukte GmbH (St. In pumpkin seed oil, the presence of lutein and β-carotene was found anywhere between 25. Pumpkin (Cucurbita spp. 9%. The seeds were cleaned and sanitized using 200 ppm chlorine solution and left to dry at ambient room temperature (30 ± 2 °C) for five hours to remove any residual moisture Majority of men are affected by symptomatic benign prostatic hyperplasia (BPH) from a certain age. 1007 For this, we used pumpkin seed oil, because it is high in unsaturated fatty acids (about 80%) and known to contain large amounts of phytochemicals [10, 11]. Secoisolariciresinol, but none of the other lignans, has so far been identified in pumpkin seeds. 15 g g −1 dm, respectively. The fruit of pumpkin including the flesh, seed, and peel are a rich source of primary and secondary metabolites, including proteins, carbohydrates, monou Pumpkin seeds (i. PUFA present in corn and pumpkin seed oils have demonstrated antihypertensive effect in clinical trials (126, 127). Response surface methodology (RSM) was applied to optimize hull-less pumpkin seed roasting conditions before seed pressing to maximize the biochemical composition and antioxidant capacity of the virgin pumpkin oils obtained using a hydraulic press. Total unsaturated fatty acid content ranged from 73. , Wädenswil, Switzerland) from pumpkin seeds of Cucurbita pepo L. The evidence shows a strong role in preventing and treating some chronic degenerative diseases. (12–14 Background: Understanding the metabolic and transcription basis of pumpkin seed oil (PSO) intervention on metabolic disease (MD) is essential to daily nutrition and health. ) seed extract and assessed its ameliorative effects on aging- and menopause-related diseases using Saos-2 cells and ovariectomized rats. 2–37 %) and oil Cucurbitaceae family members such as pumpkin and watermelon have seeds that are discarded as the by-products of food processing. In addition to fibre, pumpkin seed press cake is a source of proteins, essential fatty acids, polyunsaturated fatty acids, omega 3, 6 and 9 fatty acids, as well as significant amounts of vitamins and minerals (14–16). For this, we used pumpkin seed oil, because it is high in unsaturated fatty acids and a rich source of phytochemicals. There is so much more to this tiny seed. Protein solubility index, water and fat absorption Pumpkin seed is an excellent dietary source for protein, oil, and some essential micronutrients. ) were purchased from an agricultural product market in Gangjin-gun, Jeollanam-do, Korea. 25 g of pumpkin decoction. In short-term studies, pumpkin seed oil has been shown to reduce surrogate markers of liver health and improve dyslipidaemia [13–15]. The seed coat was peeled off, and the seeds were ground to a powder using a grinder. 2021). w) of normal saline. ) has received considerable attention in recent years because of the nutritional and health-protective value of seed oil. Objective: The objective of the present study was to investigate the active components of pumpkin seed oil and its mechanism against BPH. Hence, this study investigated the influence Drying resulted in >5 log CFU/g loss at both 51 and 60°C and ∼3 log CFU/g loss at 25°C on partially sprouted pumpkin and sunflower seeds. styriaca. , 2006). Preparation of Seeds. Dough properties were evaluated by a farinograph; loaves of breads were evaluated by a taste panel for crust color, crumb Ethnopharmacological studies showed that pumpkin seeds were used to improve the erysipelas skin contamination (Yang et al. Pumpkin seed oil ingredients are carotenoids, vitamin E and vitamin A as antioxidants, Omega-six, omega- nine fatty acid, and phytosterols (Murkovic et al. Pumpkin seeds improve sexual stimulation and intromission and ejaculatory latency 17. Extraction method for PPI was optimized by varying NaCl (0, 0. In separate groups, cocoa butter was replaced Pumpkin (Cucurbita pepo and maxima) seeds are uniquely flavored and commonly consumed as a healthy roasted snack. At the end of the treatment period, skin samples were prepared, fixed in formalin and then, sectioned and stained with hematoxylin and eosin. The ten ISSR primers generated a total number of 46 genotype-specific bands, and the total polymorphism produced in 2. 70 Various bioactive substances are also present, including polysaccharides, para-aminobenzoic acid, fatty acids, sterols, proteins, and peptides Dried seeds and nuts are widely consumed by indigenous populations of the western Sahel, especially those who inhabit rural areas. On the contrary, hull-less pumpkin seeds do not require de-hulling prior to use and are preferred by the industry . An immunohistochemical staining of MMP-9 in the diaphragm demonstrates the anti-inflammatory effects of pumpkin seed oil and albendazole (a) The negative reaction in the uninfected pumpkin-treated group (negative control in the small box); b Cytoplasmic reaction of MMP-9 positive cells were distributed around encysted larvae and between muscle We present the chemical composition, quality parameters and antioxidant capacity of pumpkin seed oils (PSO) from Cucurbita pepo, Cucurbita maxima, and Cucurbita moschata cultivated in Brazil. Methods: Formulations for bread substituted with 0%, 5% and 10% pumpkin seed and rind, respectively Knowing the powerful antioxidant properties of hull less seed of Pumpkin and its proven role in prevention of some cancers, present survey aimed to analyze the therapeutic effects of hydro-alcoholic extract of hull-less pumpkin seed (HLPS) on human PTC cell line by investigate consequence morphological alterations and a comparison with PTX was The effect of water extracts of areca nut and pumpkin seeds in the treatment of puppies experimental infected with heterophyiasis gave promising results. 002 The study further proposed that the rich protein contents with a wide range of molecular weights (3∼60 kDa) in pumpkin seeds improve insulin levels and blood glucose tolerance (Caili et al. Pumpkin-seed oil (PSO), a natural supplement rich with antioxidants and polyunsaturated fatty acids (PUFAs), was given in combination with simvastatin, as antihypercholesterolemic drug, to high cholesterol-fed rabbits, for three weeks. 8. pepo (pumpkin) seed oil was reported to possess two classes of antioxidant compounds, namely; tocopherols and phenolics, which account for 59% of the antioxidant effects. 19% in cold-pressed pumpkin seed oil to 30. A magnetic stirrer was used to periodically agitate the liquid for 24 h before filtering it through filter paper No. NCI Thesaurus (NCIt) Pumpkin seeds derived peptides bonded with natural zinc present in pumpkin seeds are excellent nutrients responsible for well-maintained immune system (Lu et al. Materials. Objectives: The current study aimed to elucidate the potential protective effect of Telfairia occidentalis (pumpkin seed oil, PSO) against hepatotoxicity induced by The effects of pumpkin seed (Cucurbita pepo) protein isolate on the activity levels of lactate dehydrogenase (LD), alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) against carbon tetrachloride (CCl4)-induced acute liver injury in low-protein fed rats were investigated. 5, 1 M) and flour-to-solut Abstract Objective. Botanical extracts are frequently used in the early management of the symptoms. Oil content ranged from 10. In the production of pumpkin seed oil, ground pumpkin seeds are mixed with water and salt to form a dough which is then roasted at 110–150 °C and pressed . This study used fifty-six (56) albino rats to determine the impact of Cucurbita pepo seed oil (CPSO) on tramadol-induced oxidative stress. Croatian oils were The aim of this study was to evaluate the effect of feed additives (pumpkin seed cake and cloves) on the egg excretion of gastrointestinal nematodes (GIN) in sheep. , 2014), acne, dermatitis, and Pumpkin seeds are often used in traditional medicine in the management of erectile dysfunction. Animals were orally administered BPA (50 mg/kg b. ) is an interesting target, as it is composed with prominent pharmacological properties to possible wound healing The main outcome of this work is elaboration of classification models for edible oil samples representing the most widespread brands of Austrian pumpkin seed oil. Thirty Ross breeder roosters (45-wk-old) were assigned into 6 groups (5 birds/group) with the following diets: Pumpkin seeds and pumpkins contain substances that assist in decreasing blood sugar, and many diabetics believe eating pumpkins will not hurt them because pumpkins have a high fiber content. Water was removed from filtrated solution by a Rotary evaporator to yield 98. This article aims to provide an evidence-based review of the literature and to explore the extraction technologies, nutritional properties, and biological activity o 2S albumins and 11S globulins, two storage proteins involved in pumpkin seeds allergy. The pumpkin seeds contain amazing amounts of vital amino Considering the presence of antioxidants and phytoestrogens in pumpkin seeds, we hypothesized that an extract of pumpkin seeds could potentially contribute to regulating lipid metabolism and oxidative stress, thereby mitigating The fruit of pumpkin including the flesh, seed, and peel are a rich source of primary and secondary metabolites, including proteins, carbohydrates, monounsaturated fatty Pumpkin seeds, regarded as by-products, discarded as household and agro-industrial wastes, have a plethora of nutritional properties, thereby, they possess the potential We provide a comprehensive overview of pumpkin seed oil chemical composition, phytochemical content, biological activity, and safety, as well as the overview of production processes and Pumpkin seeds are major oil crops with high nutritional value and high oil content. Thirty ewes naturally infected with GIN were randomly selected from a flock and assigned to the following groups of 10 animals each: clove group (received 1. Introduction: The aims of this study were to determine the proximate composition, functional properties and antioxidant activity of pumpkin seeds and rind. Regarding the Aging and menopause are associated with oxidative stress and inflammation. There was no decrease in Salmonella during drying of chia seeds at 25°C, and only drying at 60°C provided losses >5 log CFU/g. pepo var. ) are regarded for their substantial linoleic acid, important fatty acid, and high protein content. ) of pumpkin seed meal; group 2 received 1 g/kg l. Simple Summary. 5%. 2006 Jun;61(2):73-80. gov Oil-cake fats from pumpkin seeds contain large amounts of (almost 60%) of omega-3 acids twice that of cod liver oil [3–6]. Women who consume seeds 1-2 times/month had significantly lower levels of T-C and LDL-C compared to women non-consuming seeds (P < 0. There is substantial evidence demonstrating the health benefits of regularly consuming nuts. The extracts obtained were characterised by the contents of total phenolic compounds (TPC), trolox equivalent antioxidant capacity (TEAC), ferric-reducing antioxidant power (FRAP) and antiradical activity against 2,2 2. The seed-coat phenotype is an important consideration in breeding pumpkin seed cultivars. ) before either with or The extraction of the pumpkin seeds was carried out according to the maceration technique described by Siddig . ssp. 17 The pumpkin seeds yield approximately 50% oil, (mostly linoleic and oleic acid and tocopherol), but the main active constituents are sterols C. Urinary flow Pumpkin seed oil and its effects in various physiological processes. For this purpose, 48 male BALB/c mice were used. heterophyes. Using the Roth retrieval net, the remaining pumpkin seeds were removed and cleared from the rectum and sigmoid portion of the colon (). 0% (9/12) of confirmed taeniasis cases expelled whole tapeworms, but the mean time period for complete elimination was about 14 h 10 min (range 3 h 20 min to 21 h 20 min), which was much longer than that (2 h) for the study group, whereas in Control Group B treated with areca nut Pumpkin Seed Oil is the oil extracted from the seeds of Cucurbita pepo var. Melon seeds are milled and used to prepare This study evaluates the effects of pumpkin seed oil and sunflower oil along with vitamin E on the reproductive characteristics of aged roosters. Eighty Tetra SL laying hens, 50-week-old, were randomly divided into two equal groups, having 10 replicates with 4 birds in . According to Golosemiannaja and Miranda the seeds contain the This study investigated the hypoglycemic and antioxidant effects of Flax and Pumpkin seeds mixture on the kidney of alloxan-induced diabetic rats. In comparison with normal rabbits, a significant increase of the aortic contractile response to norepinephrine Raw pumpkin seeds were roasted at different temperatures (120 °C, 160 °C, and 200 °C), and then processed into milk using a high-pressure homogenizer. Pumpkin belongs to the Cucurbitaceae family, also known as cucurbits, a mid-sized plant genus that grows widely in moderate, tropical, and subtropical climates worldwide []. The seed extract had bioactive components that exhibited antioxidant Previously, it was reported that oral administration of pumpkin seed oil (PSO) improved hair growth in male pattern alopecia. The solubility of pumpkin proteins from seed flour was greatly influenced by pH changes and ionic strength, with h Seeds (Flaxseed (Linum usitatisimum), sesame seeds, sunflower seeds, and pumpkin seeds) were obtained from the Ayub Agriculture Research Center, then grounded and packed into plastic zip bags in compliances with institutional Results of pumpkin seed classification models based on pretrained models. , Cucurbita moschata or Cucurbita maxima) have been reported to possess anthelmintic properties when used in humans and livestock [22,23,24]. Dorsal hair of mice (2 x 2. Hyperplasia was induced by subcutaneous administra Abstract. Milled press cake from pumpkin (Cucurbita pepo L. Animals were allocated into three groups of six rats each: a control group (CD The seeds of the pumpkin varieties that belong to the species C. In this study, the authors investigate the protective effects of pumpkin seed oil (PSO) extract against formaldehyde-induced major organ damages in mice. The objective of this study was to consider the effectiveness of consumption of iron fortified ready-to-eat cereal and pumpkin seed kernels as two sources of dietary iron on status of iron nutrition and response of hematological characteristics of women at reproductive ages. This study aims to determine the estrogenic effects of the extract of pumpkin seeds (EPS). It contains a wide variety of bioactive compounds, including fatty acids, phytosterols, vitamins, etc. Our results suggest a high nutritional value for both cucurbit seeds and cucurbit cake, while γ-tocopherol was the richest compound, with traces of α, β and δ Background: Pumpkin (Cucurbita pepo L. 06% of men) and their preference did not cause changes in lipid profile. Testosterone alone; C. However, there is some evidence that pumpkin seeds may exert allergenic effects and induce severe life-threatening anaphylaxis. Pumpkin seeds lowered calcium-oxalate crystal occurrence and calcium level but increased phosphorus, pyrophosphate, glycosaminoglycans, and potassium values in urine as compared with orthophosphate supplementation. These effects were evaluated in Wistar rats fed with 1% cholesterol diet. fish containing the encysted metacercariae of H. In a randomised, double-blind study, the preparation Curbicin, obtained from pumpkin seeds and dwarf palm plants (Cucurbita pepo L. In this study, pumpkin seed oil (PSO) was used as a protective agent. After a week of acclimatization, rats in group 1 (normal control) had access to water and food, while rats in group 2 received 5 mL/Kg (b. This study evaluates the effects of pumpkin seed oil and sunflower oil along with vitamin E on the reproductive characteristics of aged roosters. Only 13 mg/100 g beta-sitosterol was found in pumpkin seed kernel, although total sterol content was high (265 mg/100 g). 4 mL/g) ( 8 ). Results: This study analyzed the liver metabolic variations of Wistar rats fed normal diet (CON), high-fat diet (HFD) and high-fat plus PSO diet (PSO) to establish the relationship between the liver Pumpkin seeds (C. However, potential anti-inflammatory properties have Flax and pumpkin seeds are a rich source of unsaturated fatty acids, antioxidants and fibers, known to have anti-atherogenic and hepatoprotective activities. Pumpkin seeds are a good source of essential fatty acids and bioactive molecules such as β-carotene, α-tocopherol, vitamin B, lutein, phytosterols, and other minerals []. Pumpkin seed powder is used in China and the United States as an ingredient of salad dressings and in baked products. The isolate exhibited about 80% radical scavenging activity, chelating activity of approximately 64% on Fe2+ ions and an inhibition of approximately 10% of xanthine oxidase. The biochemical, nutritional, and functional properties of the protein isolate (PPI) and protein fractions from pumpkin seed were evaluated. Pumpkin seed oil has long been considered as an ingredient for its nutritional and medicinal values for the prevention of various ailments, especially for prostate diseases. 50% ethanol is more efficient than 80% methanol when used as an extracting agent. Chocolate fortified with zinc from pumpkin seeds has been developed to overcome zinc deficiencies in COVID 19 times as a dietary supplement (Suchitra et al. γ-Tocopherol was the most abundant tocopherol (6. Pumpkin seed is the most studied nutraceutical and has shown a significant improvement in LUTS and in urological quality of life. ncbi. Besides, the effects of dietary fibre in pumpkin seeds and rinds on bread qualities and properties were evaluated. The antioxidant activity values obtained with 50% ethanol are higher than those achieved with 80% methanol. Its effect was compared with that of indomethacin, as a classical anti-inflammatory agent. Raw pumpkin seeds protein hydrolysate (PSPH) was produced by papain hydrolysis. ) seed oil is a common salad oil which is produced in the southern parts of Austria, Slovenia and Hungary. 76 male patients with AGA Pumpkin seed oil (PSO), a rich source of nutrients, is extracted from the seeds of different pumpkin varieties for food and medicines. Pumpkin-seed oil (PSO), a natural supplement rich with antioxidant ingredients, was given to rats in which arthritis was induced using Freund's complete adjuvant. Most studies have been conducted in vitro and support the claim that pumpkin seed oil has antioxidant and antimicrobial activities. One hundred patients with Benign Prostatic Hyperplasia were randomly divided into 2 equal groups receiving prostafit and prazosin, respectively. 2. The fruit of pumpkin including the flesh, seed, and peel are a rich source of primary and secondary Pumpkin seeds (Cucurbita spp. All the isoforms of vitamin E were detected in both matrices in varied amounts, while total tocopherols content was richer in raw seeds than in the seed cake (6. In vitro experiment was performed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphe Pumpkin seeds are one of the functional foods with most potential having myriad of uses, and functioning as both edible seeds and oilseeds. ) were obtained from a local packinghouse facility as a waste product from the processing of a minimally processed pumpkin product. It has a wide variety of biological activity such as antioxidant, anticancer, anti-inflammatory etc. Phytosterol concentrations were greater than reported in existing food composition databases, probably due to the inclusion of steryl glycosides, which represent a significant portion of total sterols in nuts and seeds. Hull-less pumpkin seeds were roasted for various le Exposures to hazardous chemicals including formaldehyde are harmful to human health. In light of the need for quantitative information regarding the content of particular nutrients in these plant foods, we collected dried pumpkin (Cucurbita spp) seeds and nuts of Cyperus esculentus in the Republic of Niger and analyzed them for their In Control Group A with treatment of pumpkin seeds alone, 75. The seeds and oil from pumpkin seeds have been used for many years for the relief of difficulties associated with an enlarged prostate gland and micturition problems related to irritable bladder. The predominant fatty acids present were Pumpkin is a well-known vegetable, among the members of Cucurbitaceae family, due to its importance as pharma food. In this study we aim to evaluate the potential of these wastes as sources of beneficial and bioactive compounds (antioxidants and antimicrobials), studying the effect of different extraction solvents and drying methods. [ 31 ] The antioxidative effects of pumpkin seed protein isolate (Cucurbita pepo) were investigated in vitro. Methods. doi: 10. 05). Available from https://pubmed. Group 1 Cucurbita moschata (Pumpkin) seeds contain a variety of compounds, such as m-carboxyphenylalanine, amino butyrate, and citrulline, as well as a number of other amino acids. Results: In this study, 100 mice were divided into five groups: an infected This study showed the significance of oil from pumpkin seeds (Cucurbita pepo L. Pumpkin seed oil is also well known for its distinctive colour, usually described as dark green with strong red fluorescence, which is due to its dichromatic character . 8 g ground cloves/ewe Abstract. 01). Lung tissue from MTX-treated group revealed a decrease in malondialdehyde, glutathione, and nitric oxide accompanied by a marked inhibition in cholinesterase activity, and enhanced catalase activity, tumor necrosis factor-α Effects of phytoestrogen extracts isolated from pumpkin seeds on estradiol production and ER/PR expression in breast cancer and trophoblast tumor cells Pumpkin seeds are traditionally implicated for their pharmacological properties, as exemplified by benign prostatic hyperplasia. The ability of a 15% Telfairia occidentalis seeds incorporated diet to inhibit hormonal induction of BPH in rats was studied. A group of male Sprague-Dawley rats The main phytochemicals in pumpkin seed oil with health-related properties are polyphenols, phytoestrogens, and fatty acids, but carotenoids, squalene, tocopherols, and minerals may also contribute to health benefits. We report here a case of food anaphylaxis to pumpkin seed in an eight-year-old boy, who tolerated all other edible seeds, peanut and tree nuts, as well as pulp of different kinds of pumpkins and other fruits of the Cucurbitaceae family. The first limiting amino acid was lysine for both watermelon and pumpkin seed kernel flours, but it was leucine in paprika seed flour. Thirty Ross breeder roosters (45-wk-old) were assigned into 6 groups (5 birds/group) with the following diets: The pumpkin seeds were spread uniformly in preheated trays and were roasted at 120, 160, and 200°C for 10 min, respectively, using a NB-HM3810 oven (Panasonic Corporation, Osaka, Japan). In addition, PSO nanoemulsions (nanopepo, nanomax and nanomosc) were developed and their physical stabilitie Fatty acid, carotenoids, tocopherol, polyphenol and sterol composition of pumpkin seeds from different varieties changed in three distinct time periods from seed establishment to final crop time, according to a study that measured the seed and oil yields, protein, and moisture ratios of four different types of pumpkin seed varieties (Dülger Objectives: Pumpkin and its seeds are increasingly consumed by children for their potential health benefits. A complete spectral characterisation of the pumpkin seed oil samples by UV-Vis, NIR and FTIR spectra was obtained together with their bas The observed associations were not differential by ER status. As a whole, pumpkin’s oil would be recommended in the nutritional and medicinal purposes. It is dark green and has a high content of free fatty acids. This study aimed to evaluate hair promoting activity of topical PSO in an animal model. Subsequently the effect Pumpkin seeds are rich source of nutritionally well-balanced proteins. Group 1 consists of animals treated with 0. BPH is associated with the inflammation of the prostate gland and overexpression of cytokines, leukotriene, inducible nitric oxide synthase, NF-κB, and cyclooxygenase-2 is linked with prostatitis [ 27 ]. 18 g/100 g dw, respectively). We have assessed the possible protective efficacy of pumpkin seed extract on sperm characteristics, biochemical parameters and epididy Cancer treatment with cyclophosphamide (CP) may result in reproductive toxicity as one of its side effects. Pumpkin (Cucurbita pepo) is cultivated for human utilization and as functional food or medicine . 67% in cold-pressed pumpkin seed oil . ) seed oil is a common salad oil which is produced in Slovenia, Hungary and the southern parts of Austria. Oxidative stress has been proposed as a possible mechanism involved in NO3 toxicity on non-target organism. However, they have been discovered to contain a rich repertoire of nutrients such as proteins, unsaturated fatty acids, phenolic acids, carotenoids, tocopherol, phytosterol, squalene etc. We examined the effects of PSO supplementation on vascular function and heart rate variability (HRV) in postmenopausal women with elevated blood pressure (BP). In addition, Cucurbita pepo L was used in some countries for treating burns and wounds (Ejaz et al. ; and Group 4 was the control group and do not received treatment. However, the pumpkin seed albumin concentrate had similar oil-holding capacity to the albumin concentrate from African locust bean (3. As compared with the T-P-alone rats, the TP rats treated with pumpkin seed oil alone or pumpkin seed oil combined with Phytosterol-F had a significantly lower weight ratio for the ventral prostate (p=0. This concentration is equivalent to +/- 73 pumpkin seeds (x2 = 5. Background: Benign prostatic hyperplasia (BPH) is very common in aging men. It can protect against other diseases as well as reduce the risk of cardiovascular disease, some cancers and other health conditions. Biological assays have proven the seed extracts to exert Introduction: Pumpkins are thought to be useful in the management of benign prostatic hyperplasia (BPH). Earlier, pumpkin seed proteins were extracted by the Osborne method, and their functional and nutritional qualities were evaluated. The chemical composition of the seeds was performed according to the official methods of American Oil Chemists' Society and Association of The spectroscopic properties of pumpkin seeds were used to quantify the fat, moisture, protein, ash, fiber, and total carbohydrate contents. styriaca GREB. 59 g/100 g dw Phenolic compounds were extracted from pumpkin (Cucurbita pepo) seed and amaranth (Amaranthus caudatus) grain into 80% (v/v) methanol. Apart from different extraction methods, the solvents used in the Background: This study aimed to investigate the antiparasitic and anti-inflammatory potential of pumpkin seed oil in mice infected with Trichinella spiralis by demonstrating its impact on MMP-9 expression and pathogenesis during the intestinal and muscular phases. 26–162. e. Several studies have demonstrated that pumpkin seeds and daily rich diet of zinc can decrease the undesirable side effect of lead contaminants and improve the sexual health status 16. ) has received considerable attention because of the nutritional and health-protective value of its seed oil. 03 and p=0. Methods: ApoE*3Leiden mice were fed a Western-type diet (CON) containing cocoa butter (15% w/w) and cholesterol (1% w/w) for 20 weeks to induce risk factors and disease endpoints. nih. In addition, several studies have suggested the crucial roles and effectiveness of Macro‐ and microelements in the samples of virgin and cold pressed pumpkin seed oils produced in Croatia through two consecutive crop seasons were determined by inductively coupled plasma–optical emission spectroscopy (ICP‐OES). Nevertheless, their utilization is restricted to the presence of a thick seed coat (hull) which subjects them to the process of decortication, increasing the farmers’ expense as well as limiting their utilization as oilseeds. This study aims to investigate the effects of different pretreatment techniques on the stability of Pumpkin Seed Milk (PSM) and explore potential mechanisms. Total phenolic compounds were determined using the Folin-Ciocalteau reagent according to the method described by Bouaziz et al 15. 5 cm) was gently removed. 27 Zhang After the removal of the pulp and flesh from pumpkin squash still remains a large quantity of shell and seeds as waste products. Each day, approximately 30% of teenagers consume nuts and seeds, including pumpkin seeds. Pumpkin seeds provide high phosphorus levels and can be used as a potential agent in lowering the risk of bladder-stone disease. 5 g/kg live weight (l. 1 to 80. This investigation seeks to examine the effect of pumpkin seed oil on testosterone-induced hyperplasia of the prostate of rats. Flaxseed has been reported to contain glycosides of secoisolariciresinol as the major lignan, together with small amounts of matairesinol, isolariciresinol, and pinoresinol. Pumpkin seeds represent a valuable source of plant protein and can be utilized in the production of plant-based milks. The pumpkin seed is a rich natural source of antioxidant. The seed itself can be eaten. Hydrogenated Pumpkin Seed Oil chemical information summary. Pumpkin cultivars with hulled seeds must be mechanically de-hulled prior to use in certain markets, thus adding to production cost. Pumpkin seeds contain lignan phytoestrogens, which have the potential to retrieve menopausal syndromes caused by estrogen deficiency. Both raw pumpkin seeds and roasted ones were grounded into flours using a YF-1000 blender (Yongli Pharmaceutical Mechanic, Hangzhou, Zhejiang, China). Testosterone+pumpkin seed oil (10%); E. Testosterone+Minoxidil 2%. Subjects and methods: A total of 1,431 men (50-80 years) with The richest known dietary source of lignans is flaxseed. It also contains L-ascorbic acid, which is the most important and abundant intracellular and extracellular aqueous-phase antioxidant. and Sabal serrulata), was compared with a placebo in the treatment of symptoms caused by prostatic hyperplasia; 53 patients took part in the study, which was carried out over a 3-month period. Pumpkin by-products such as seeds, and pomace can be a source of nutrients for aquatic organisms. Ruprecht an der Raab, Austria). However, the community's use of pumpkin seeds is still limited. Methods of the Study. gov/21106396/ Fu Caili, Shi Huan, Li Quanhong. ), was evaluated. 6, p<0. Testosterone+pumpkin seed oil (5%); D. 003, respectively; p=0. The collection and identification of different pumpkin germplasm resources play a significant Diet supplemented with roasted pumpkin seeds showed better PDE-5, ADA, arginase activities, as well as NO and MDA levels. Dried seeds were stored at 37 and 45°C at 15 and 76% relative humidity (RH The oil from the pumpkin (Cucurbita pepo) seed is claimed to be useful in the management of benign prostatic hyperplasia. Pumpkin seed oil (PSO) has been shown to block the action of 5-alpha reductase and to have antiandrogenic effects on rats. nlm. ), cultivated in Iowa, were studied for their seed oil content, fatty acid composition, and tocopherol content. Keywords: Pumpkin seed oil, Fatty acids, Tocopherols, Phytosterols, Wound healing. This is in contrast to the proprietary oil-free hydroethanolic pumpkin seed extract (EFLA ® 940; Frutarom Switzerland Ltd. , 2007). The objective of this study was to investigate the effect of dietary pumpkin (Cucurbita moschata) seed meal (PSM) on laying hens’ performance, quality, fatty acids, cholesterol, antioxidant compounds and shelf life of eggs. . Pumpkin seeds are often utilized directly for human consumption as snacks after salting and roasting in many Arabian countries and these seeds have been reported as excellent sources of protein (25. No statistically significant associations were found for dietary intake of plant lignans, fiber, or the calculated enterolignans. However, its active components and mechanism have remained to be elucidated. Materials and methods: Male Swiss mice (25-30 g) were used. 74 mL/g) and Ginkgo seed (0. The study analyzed the microstructure, viscosity, particle size, physical stability, centrifugal stability, salt concentration, heat treatment, freeze-thaw cycle, and environment stress In this study, pumpkin seeds peptide was purified, characterized, and evaluated for their zinc-chelating capability, as well as in vitro bioaccessibility and transportation. 96 g/100 g dw and 1. In men, we did not observed This study was aimed at the investigation of the antioxidant effect of pumpkin seed oil against the oxidative stress-inducing potential of aflatoxin. We aimed to compare the effects of tamsulosin and pumpkin (Cucurbita pepo) seed oil on BPH symptoms. The loss dropped rapidly as the model accuracy raised over 100 iterations. A circumferential stercoral ulceration was seen in the rectum with marked edema and erythema (). A review on pharmacological activities and utilization technologies of pumpkin. Keeping in view the antidiabetic and plasma lipids lowering potential of pumpkin, the present study was conducted to investigate that, which part of pumpkin (peel, flesh, and seeds), possess more bioactive compounds, exhibiting antihyperglycemic and Pumpkin seeds oil (PSO) was used to investigate its ability to alleviate methotrexate-induced lung toxicity in rats. 50 gm of powdered seeds were put in a conical flask. Animals were allocated into three groups of six rats each: a control group (CD), a diabetic group (DD) and diabetic rats fed with Flax and Pumpkin seeds Natural products like pumpkin-seed oil (PSO) may modify the potency of the calcium antagonist felodipine (FEL) or angiotensin-converting enzyme inhibitor (ACE-inhibitor), captopril (CPT) in modulating the biochemical derangement in blood, heart and kidney as well as blood pressure and heart rate of spontaneously hypertensive rats (SHR) were investigated. Commercialised Oil was prepared by pressing roasted pumpkin seeds in Pakistan. Pumpkin seed press cake, a by-product of oil production, is a food resource that offers various health benefits. A. Review Plant Foods Hum Nutr. Decoctions of pump Food allergy to pumpkin seed is considered very rare, and only some isolated case reports have so far been published. It was found that the MIC of 23 gr. 500 ml of 70% ethanol was poured on. Treatments continued once daily, 6 days a week for 3 weeks. 9 to 30. These animals were divided into four groups of 12 ostriches. 2021 ). The classification results of 75 categories of pumpkin seeds by fine-tuning 6 pretrained models are shown in Table 4, and the loss and accuracy curves are shown in Fig. , 2000). In particular, the lipid fraction of seed oil was characterized, and the triacylglycerol (TAG) was Pumpkin seed oil is a natural product commonly used in folk medicine for treatment of prostatic hypertrophy. In a study evaluating the inclusion of Japanese pumpkin seeds and pomace in the diet of the Pacific white shrimp Penaeus vannamei, we found that the seeds had a negative effect on shrimp performance and a pro-oxidative effect on muscle, Cucurbita moschata (Pumpkin) seeds contain a variety of compounds, such as m-carboxyphenylalanine, amino butyrate, and citrulline, as well as a number of other amino acids. w. Raw pumpkin seed may have a compromised flavor, color, as well as digestibility. Such studies are still few in number, however, and reports of the The content of oleic acid ranged from 28. Due to its colour, the oil cannot be used for cooking. Evidence from animal studies have demonstrated the antihypertensive effects of pumpkin seed oil (PSO). Determination of total phenols. hbn uvxkci psrdw adoarru snvf qbtla oieo zuvyx lidd oyej